Journal article

Common andgender-specificassociations with cocaine use on gray matter volume: Data from theENIGMAaddiction working group

Rachel A Rabin, Scott Mackey, Muhammad A Parvaz, Janna Cousijn, Chiang-shan Li, Godfrey Pearlson, Lianne Schmaal, Rajita Sinha, Elliot Stein, Dick Veltman, Paul M Thompson, Patricia Conrod, Hugh Garavan, Nelly Alia-Klein, Rita Z Goldstein

HUMAN BRAIN MAPPING | WILEY | Published : 2020

Abstract

Gray matter volume (GMV) in frontal cortical and limbic regions is susceptible to cocaine-associated reductions in cocaine-dependent individuals (CD) and is negatively associated with duration of cocaine use. Gender differences in CD individuals have been reported clinically and in the context of neural responses to cue-induced craving and stress reactivity. The variability of GMV in select brain areas between men and women (e.g., limbic regions) underscores the importance of exploring interaction effects between gender and cocaine dependence on brain structure. Therefore, voxel-based morphometry data derived from the ENIGMA Addiction Consortium were used to investigate potential gender diff..

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Grants

Awarded by NHMRC Career Development Fellowship


Awarded by NIDA



Funding Acknowledgements

This work was supported by a T32 DA007135 to Rachel A. Rabin; U54 EB 020403 with funds provided for the trans-NIH Big Data to Knowledge (BD2K) initiative to Scott Mackey; K01DA043615 to Muhammad A. Parvaz; R01DA023248 and R21DA044749 to Chiangshan Li; NHMRC Career Development Fellowship (1140764) to Lianne Schmaal; P50-DA016556; R01-AA013892 and Ul1-DE024859 to Rajita Sinha; Intramural Research Program of NIH to Elliot Stein; R01MH117601 to Paul M. Thompson; NIDA grants 1R21DA038381 and 1R01DA047119-01 to Hugh Garavan; and an R01DA041528, R01DA047851 and 1R01DA04830-01A1 to Rita Z. Goldstein.