Medullary tyrosine hydroxylase catecholaminergic neuronal populations in sudden unexpected death in epilepsy
Smriti Patodia, Ian Tan, Matthew Ellis, Alyma Somani, Ingrid E Scheffer, Sanjay M Sisodiya, Maria Thom
Brain Pathology | WILEY | Published : 2020
Sudden unexpected death in epilepsy (SUDEP) is mechanistically complex and one probable cause is seizure-related respiratory dysfunction. Medullary respiratory regulatory nuclei include the pre-Bötzinger complex (pre-BötC) in the ventrolateral medulla (VLM), the medullary raphé nuclei (MR) and nucleus of solitary tract in the dorsomedial medulla (DMM). The region of the VLM also contains intermingled tyrosine hydroxylase (TH) catecholaminergic neurones which directly project to the pre-BötC and regulate breathing under hypoxic conditions and our aim was to evaluate these neurones in SUDEP cases. In post-mortem cases from three groups [SUDEP (18), epilepsy controls (8) and non-epilepsy contro..View full abstract
Awarded by National Institute of Neurological Disorders And Stroke of the National Institutes of Health
UCL is part of the Center for SUDEP Research (CSR) and supported through the National Institute of Neurological Disorders And Stroke of the National Institutes of Health (Award Numbers neuropathology of SUDEP: 5U01NS090415 and SUDEP admin core grant: U01-NS090405). Epilepsy Society supports SMS, and through the Katy Baggott Foundation, supports the UCL Epilepsy Society Brain and Tissue Bank. This work was undertaken at UCLH/UCL who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme. We are very grateful for provision of additional SUDEP and control material for this study from the following resources: The MRC Sudden Death Brain Bank in Edinburgh (cases detailed in additional methods file). Tissue samples were also obtained from David Hilton at Derriford Hospital as part of the UK Brain Archive Information Network (BRAIN UK) which is funded by the Medical Research Council and Brain Tumour Research.