Journal article
Long-term glycemic variability and vascular complications in type 2 diabetes: post hoc analysis of the FIELD study
ES Scott, AS Januszewski, R O’Connell, G Fulcher, R Scott, A Kesaniemi, L Wu, S Colagiuri, A Keech, AJ Jenkins
Journal of Clinical Endocrinology and Metabolism | ENDOCRINE SOC | Published : 2020
Abstract
Aims: To investigate whether long-term glycemic variability (GV) is associated with vascular complication development in type 2 diabetes. Methods: In a post hoc FIELD trial analysis, GV was calculated as the standard deviation and coefficient of variation (CV) of glycated hemoglobin A1c (HbA1c) and fasting plasma glucose. Baseline variables were compared across quartiles of on-study variability by chi square and ANOVA. Prospective associations between baseline to 2-year GV and subsequent vascular and mortality outcomes were analyzed using landmark logistic and Cox proportional hazards regression. Results: Baseline factors associated with higher on-study GV included younger age, male gender, ..
View full abstractGrants
Funding Acknowledgements
The FIELD study was supported by funding from Laboratoires Fournier SA, Dijon, France (part of Solvay Pharmaceuticals, then Abbott and Mylan), and National Health and Medical Research Council (NHMRC) of Australia Program Grants. ES is supported by funding from Juvenile Diabetes Resarch Foundation and the Royal Australian College of Physicians. ACK is supported by an NHMRC Fellowship. AJJ is supported by an NHMRC Practitioner Fellowship and is a Sydney Medical School Foundation Fellow.