Metabolic cooperativity betweenPorphyromonas gingivalisandTreponema denticola
Lin Xin Kin, Catherine A Butler, Nada Slakeski, Brigitte Hoffmann, Stuart G Dashper, Eric C Reynolds
JOURNAL OF ORAL MICROBIOLOGY | TAYLOR & FRANCIS LTD | Published : 2020
Background: Porphyromonas gingivalis and Treponema denticola are proteolytic periodontopathogens that co-localize in polymicrobial subgingival plaque biofilms, display in vitro growth symbiosis and synergistic virulence in animal models of disease. These symbioses are underpinned by a range of metabolic interactions including cooperative hydrolysis of glycine-containing peptides to produce free glycine, which T. denticola uses as a major energy and carbon source. Objective: To characterize the P. gingivalis gene products essential for these interactions. Methods: The P. gingivalis transcriptome exposed to cell-free T. denticola conditioned medium was determined using RNA-seq. P. gingivalis..View full abstract
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Awarded by Australian National Health and Medical Research Council
Awarded by Australian Government Department of Industry, Innovation and Science Grant
This work was supported by the Australian National Health and Medical Research Council Project Grant ; Australian Government Department of Industry, Innovation and Science Grant .