Journal article

Metabolic cooperativity betweenPorphyromonas gingivalisandTreponema denticola

Lin Xin Kin, Catherine A Butler, Nada Slakeski, Brigitte Hoffmann, Stuart G Dashper, Eric C Reynolds

JOURNAL OF ORAL MICROBIOLOGY | TAYLOR & FRANCIS LTD | Published : 2020

Abstract

Background:  Porphyromonas gingivalis and Treponema denticola are proteolytic periodontopathogens that co-localize in polymicrobial subgingival plaque biofilms, display in vitro growth symbiosis and synergistic virulence in animal models of disease. These symbioses are underpinned by a range of metabolic interactions including cooperative hydrolysis of glycine-containing peptides to produce free glycine, which T. denticola uses as a major energy and carbon source. Objective:  To characterize the P. gingivalis gene products essential for these interactions. Methods: The P. gingivalis transcriptome exposed to cell-free T. denticola conditioned medium was determined using RNA-seq. P. gingivalis..

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