Journal article

Childhood maltreatment and cognitive functioning: the role of depression, parental education, and polygenic predisposition

Janik Goltermann, Ronny Redlich, Dominik Grotegerd, Katharina Dohm, Elisabeth J Leehr, Joscha Boehnlein, Katharina Foerster, Susanne Meinert, Verena Enneking, Maike Richter, Jonathan Repple, Immanuel DeVillers, Marine Kloecker, Andreas Jansen, Axel Krug, Igor Nenadic, Katharina Brosch, Tina Meller, Frederike Stein, Simon Schmitt Show all



Childhood maltreatment is associated with cognitive deficits that in turn have been predictive for therapeutic outcome in psychiatric patients. However, previous studies have either investigated maltreatment associations with single cognitive domains or failed to adequately control for confounders such as depression, socioeconomic environment, and genetic predisposition. We aimed to isolate the relationship between childhood maltreatment and dysfunction in diverse cognitive domains, while estimating the contribution of potential confounders to this relationship, and to investigate gene-environment interactions. We included 547 depressive disorder and 670 healthy control participants (mean ag..

View full abstract

University of Melbourne Researchers


Awarded by DFG

Funding Acknowledgements

This work is part of the German multicenter consortium "Neurobiology of Affective Disorders. A translational perspective on brain structure and function", funded by the German Research Foundation (Deutsche Forschungsgemeinschaft DFG; Forschungsgruppe/Research Unit FOR2107). Principal investigators (PIs) with respective areas of responsibility and funding in the FOR2107 consortium are: Work Package WP1, FOR2107/MACS cohort and brainimaging: TK (speaker FOR2107; DFG grant numbers KI 588/14-1, KI 588/14-2), UD (co-speaker FOR2107; DA 1151/5-1, DA 1151/5-2), AK (KR 3822/5-1, KR 3822/7-2), IN (NE 2254/1-2), Carsten Konrad (KO 4291/3-1). WP5, genetics: MRietschel (RI 908/11-1, RI 908/11-2), MN (NO 246/10-1, NO 246/10-2), SW (WI 3439/3-1, WI 3439/3-2). WP6, multi-method data analytics: AJ (JA 1890/7-1, JA 1890/7-2), Tim Hahn (HA 7070/2-2), Bertram Muller-Myhsok (MU1315/8-2), Astrid Dempfle (DE 1614/3-1, DE 1614/3-2). CP1, biobank: Petra Pfefferle (PF 784/1-1, PF 784/1-2), Harald Renz (RE 737/20-1, 737/20-2). CP2, administration. TK (KI 588/15-1, KI 588/17-1), UD (DA 1151/6-1), Carsten Konrad (KO 4291/4-1). Data access and responsibility: All PIs take responsibility for the integrity of the respective study data and their components. All authors and coauthors had full access to all study data. The FOR2107 cohort project (WP1) was approved by the Ethics Committees of the Medical Faculties, University of Marburg (AZ: 07/14) and University of Munster (AZ: 2014-422-b-S). Biomedical financial interests or potential competing interests: TK received unrestricted educational grants from Servier, Janssen, Recordati, Aristo, Otsuka, neuraxpharm. No further potential competing interests are declared by the authors. Open access funding provided by Projekt DEAL.