Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice
Ellen Menkhorst, Wei Zhou, Leilani L Santos, Sarah Delforce, Teresa So, Kate Rainczuk, Hannah Loke, Argyro Syngelaki, Swati Varshney, Nicholas Williamson, Kirsty Pringle, Morag J Young, Kypros H Nicolaides, Yves St-Pierre, Eva Dimitriadis
Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
Preeclampsia is a serious pregnancy-induced disorder unique to humans. The etiology of preeclampsia is poorly understood; however, poor placental formation is thought causal. Galectin-7 is produced by trophoblast and is elevated in first-trimester serum of women who subsequently develop preeclampsia. We hypothesized that elevated placental galectin-7 may be causative of preeclampsia. Here, we demonstrated increased galectin-7 production in chorionic villous samples from women who subsequently develop preterm preeclampsia compared with uncomplicated pregnancies. In vitro, galectin-7 impaired human first-trimester trophoblast outgrowth, increased placental production of the antiangiogenic sFlt..View full abstract
Awarded by NHMRC (Australia)
Funding: NHMRC (Australia) Project/Program Grant (GNT1098332) and Fellowships (#550905; E. Dimitriadis; #611827; E. Menkhorst); Rebecca L Cooper Medical Research Foundation Project Grant; Trevor B Kilvington Bequest Foundation and the Victorian Government's Operational Infrastructure Support Program.