Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer's Disease
Jeremiah KH Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Holly R Chinnery, Jamie Mullen, Bang V Bui, Christine TO Nguyen
Frontiers in Neuroscience | FRONTIERS MEDIA SA | Published : 2020
Alzheimer's disease is characterized by the aberrant deposition of protein in the brain and is the leading cause of dementia worldwide. Increasingly, there have been reports of the presence of these protein hallmarks in the retina. In this study, we assayed the retina of 5xFAD mice, a transgenic model of amyloid deposition known to exhibit dementia-like symptoms with age. Using OCT, we found that the retinal nerve fiber layer was thinner in 5xFAD at 6, 12, and 17 months of age compared with wild-type littermates, but the inner plexiform layer was thicker at 6 months old. Retinal function showed reduced ganglion cell responses to light in 5xFAD at 6, 12, and 17 months of age. This functional ..View full abstract
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Awarded by Australian Research Council (ARC)
Awarded by ARC Future Fellowship Award
This research was supported by the Australian Research Council (ARC) Linkage Grant (LP160100126), the ARC Future Fellowship Award (FT130100388), Melbourne Research Fellowship, Melbourne Neuroscience Institute Fellowship, Melbourne School of Health Sciences Seed funding, and the Melbourne Neuroscience Institute Strategic Postgraduate Award (STRAPA).