Journal article

Overlapping Peptides Elicit Distinct CD8( ) T Cell Responses following Influenza A Virus Infection

Lisa M Assmus, Jing Guan, Ting Wu, Carine Farenc, Xavier YX Sng, Pirooz Zareie, Angela Nguyen, Andrea T Nguyen, David C Tscharke, Paul G Thomas, Jamie Rossjohn, Stephanie Gras, Nathan P Croft, Anthony W Purcell, Nicole L La Gruta

The Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2020

Abstract

The presentation of pathogen-derived peptides on MHC class I molecules is essential for the initiation of adaptive CD8+ T cell immunity, which in turn is critical for effective control of many significant human infections. The identification of immunogenic pathogen-derived epitopes and a detailed understanding of how they are recognized by TCRs is essential for the design of effective T cell-based vaccines. In this study, we have characterized the T cell recognition and immune responses in mice to two naturally presented influenza A virus-derived peptides previously identified from virally infected cells via mass spectrometry. These neuraminidase-derived peptides, NA181-190 (SGPDNGAVAV) and ..

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Grants

Awarded by Australian Research Council (ARC)


Awarded by National Health and Medical Research Council Program


Awarded by ARC Discovery Project


Awarded by ARC


Awarded by National Institutes of Health


Awarded by Bonn and Melbourne Research and Graduate School


Awarded by National Health and Medical Research Council


Funding Acknowledgements

This work was supported by a Sylvia and Charles Viertel Senior Medical Research Fellowship, Australian Research Council (ARC) Future Fellowship FT170100174, National Health and Medical Research Council Program Grant APP1071916 and Project Grant APP1084283, ARC Discovery Project DP170103631 (to N.L.L.G.), ARC funding (CE140100011), an ARC Laureate Fellowship (to J.R.), National Institutes of Health funding (AI136514) (to P.G.T.), a Monash University Biomedicine Discovery Scholarship (to X.Y.X.S.), funding from the Bonn and Melbourne Research and Graduate School (GRK2168) (to L.M.A.), and National Health and Medical Research Council Senior Research Fellowship APP1104329 (to D.C.T.).