Journal article

Mortality Effects of Hypothetical Interventions on Physical Activity and TV Viewing

Yi Yang, Allison M Hodge, Pierre-Antoine Dugue, Elizabeth J Williamson, Paul A Gardiner, Elizabeth LM Barr, Neville Owen, David W Dunstan, Brigid M Lynch, Dallas R English



INTRODUCTION: Long-term effects of physical activity and television (TV) viewing on mortality have been inferred from observational studies. The associations observed do not allow for inferences about the effects of population interventions and could be subject to bias due to time-varying confounding. METHODS: Using data from the Australian Diabetes, Obesity and Lifestyle Study, collected in 1999-2000 (T0), 2004-2005 (T1), and 2011-2012 (T2), we applied the parametric g-formula to estimate cumulative risks of death under hypothetical interventions on physical activity and/or TV viewing determined from self-report while adjusting for time-varying confounding. RESULTS: In the 6377 participants..

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Awarded by Victorian Cancer Agency

Awarded by National Health andMedical Research Council

Funding Acknowledgements

The authors thank the participants and staff of The Australian Diabetes, Obesity and Lifestyle study for their valuable contributions. Y. Y. is supported by aMelbourne Research Scholarship from the University of Melbourne. B. M. L. is supported by a fellowship from the Victorian Cancer Agency (MCRF-18005). The Australian Diabetes, Obesity and Lifestyle study is supported by a National Health and Medical Research Council project grant (233200), Australian Government Department of Health and Ageing. In addition, the study has received financial support from the Abbott Australasia, Alphapharm, AstraZeneca, Aventis Pharma, Bio-Rad Laboratories, Bristol-Myers Squibb, City Health Centre Diabetes Service Canberra, Department of Health and Community Services Northern Territory, Department of Health and Human Services Tasmania, Department of Health New South Wales, Department of Health Western Australia, Department of Human Services South Australia, Department of Human Services Victoria, Diabetes Australia, Diabetes Australia Northern Territory, Eli Lilly Australia, Estate of the Late Edward Wilson, GlaxoSmithKline, Highpoint Shopping Centre, JackBrockhoff Foundation, Janssen-Cilag, Kidney Health Australia, Marian & EH Flack Trust, Menzies Research Institute, Merck Sharp & Dohme, Multiplex, Novartis Pharmaceuticals, Novo Nordisk Pharmaceuticals, Pfizer Pty Ltd, Pratt Foundation, Queensland Health, Roche Diagnostics Australia, Royal Prince Alfred Hospital Sydney, and Sanofi-Synthelabo.