Journal article

The effect of 17 beta-estradiol on maternal immune activation-induced changes in prepulse inhibition and dopamine receptor and transporter binding in female rats

Alyssa Sbisa, Snezana Kusljic, Damon Zethoven, Maarten van den Buuse, Andrea Gogos

Schizophrenia Research | ELSEVIER | Published : 2020

Abstract

Maternal immune activation (MIA) during pregnancy is associated with an increased risk of development of schizophrenia in later life. 17β-estradiol treatment may improve schizophrenia symptoms, but little is known about its efficacy on MIA-induced psychosis-like behavioural deficits in animals. Therefore, in this study we used the poly(I:C) neurodevelopmental model of schizophrenia to examine whether MIA-induced psychosis-like behavioural and neurochemical changes can be attenuated by chronic treatment (2-6 weeks) with 17β-estradiol. Pregnant rats were treated with saline or the viral mimetic, poly(I:C), on gestational day 15 and adult female offspring were tested for changes in prepulse inh..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

AG is supported by a Career Development Fellowship from the National Health and Medical Research Council of Australia (ID 1108098). The authors gratefully acknowledge the financial support of the Jared Purton Foundation and the One-in-Five Foundation. The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government's Operational Infrastructure Support Grant.