Journal article

Compassionate drug (mis)use during pandemics: lessons for COVID-19 from 2009

Amanda M Rojek, Genevieve E Martin, Peter W Horby

BMC MEDICINE | BMC | Published : 2020

Abstract

BACKGROUND: New emerging infections have no known treatment. Assessing potential drugs for safety and efficacy enables clinicians to make evidence-based treatment decisions and contributes to overall outbreak control. However, it is difficult to launch clinical trials in the unpredictable environment of an outbreak. We conducted a bibliometric systematic review for the 2009 influenza pandemic to determine the speed and quality of evidence generation for treatments. This informs approaches to high-quality evidence generation in this and future pandemics. METHODS: We searched PubMed for all clinical data (including clinical trial, observational and case series) describing treatment for patient..

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University of Melbourne Researchers