Compassionate drug (mis)use during pandemics: lessons for COVID-19 from 2009
Amanda M Rojek, Genevieve E Martin, Peter W Horby
BMC MEDICINE | BMC | Published : 2020
BACKGROUND: New emerging infections have no known treatment. Assessing potential drugs for safety and efficacy enables clinicians to make evidence-based treatment decisions and contributes to overall outbreak control. However, it is difficult to launch clinical trials in the unpredictable environment of an outbreak. We conducted a bibliometric systematic review for the 2009 influenza pandemic to determine the speed and quality of evidence generation for treatments. This informs approaches to high-quality evidence generation in this and future pandemics. METHODS: We searched PubMed for all clinical data (including clinical trial, observational and case series) describing treatment for patient..View full abstract
Awarded by Wellcome Trust
This work was supported by the Wellcome Trust[grant numbers 107834/Z/15/Z and 106491/Z/14/Z]. AR is supported by Open Philanthropies.