The Measles Virus V Protein Binding Site to STAT2 Overlaps That of IRF9
Yuma Nagano, Aoi Sugiyama, Madoka Kimoto, Takuya Wakahara, Yasuyo Noguchi, Xinxin Jiang, Shinya Saijo, Nobutaka Shimizu, Nana Yabuno, Min Yao, Paul R Gooley, Gregory W Moseley, Takashi Tadokoro, Katsumi Maenaka, Toyoyuki Ose
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2020
Measles virus (MeV) is a highly immunotropic and contagious pathogen that can even diminish preexisting antibodies and remains a major cause of childhood morbidity and mortality worldwide despite the availability of effective vaccines. MeV is one of the most extensively studied viruses with respect to the mechanisms of JAK-STAT antagonism. Of the three proteins translated from the MeV P gene, P and V are essential for inactivation of this pathway. However, the lack of data from direct analyses of the underlying interactions means that the detailed molecular mechanism of antagonism remains unresolved. Here, we prepared recombinant MeV V protein, which is responsible for human JAK-STAT antagon..View full abstract
Awarded by Japan Society for the Promotion of Science
Awarded by Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research [BINDS]) from the Agency for Japan Medical Research and Development (AMED)
This work was supported in part by the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research KAKENHI (grant no. 17K07296). This research was also supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research [BINDS]) from the Agency for Japan Medical Research and Development (AMED) under grant no. 17am0101093j0001, 18am0101093j0002, and 19am0101093j0003; by the Hokkaido University, Global Facility Center (GFC), Pharma Science Open Unit (PSOU), funded by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) under the "Support Program for Implementation of New Equipment Sharing System"; by the Hokkaido University Biosurface Project; and by the Takeda Science Foundation.