Population genomics identifies a distinct Plasmodium vivax population on the China-Myanmar border of Southeast Asia
Awtum M Brashear, Qi Fan, Yubing Hu, Yuling Li, Yan Zhao, Zenglei Wang, Yaming Cao, Jun Miao, Alyssa Barry, Liwang Cui
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2020
Plasmodium vivax has become the predominant malaria parasite and a major challenge for malaria elimination in the Greater Mekong Subregion (GMS). Yet, our knowledge about the evolution of P. vivax populations in the GMS is fragmental. We performed whole genome sequencing on 23 P. vivax samples from the China-Myanmar border (CMB) and used 21 high-coverage samples to compare to over 200 samples from the rest of the GMS. Using genome-wide single nucleotide polymorphisms (SNPs), we analyzed population differentiation, genetic structure, migration and potential selection using an array of methods. The CMB parasites displayed a higher proportion of monoclonal infections, and 52% shared over 90% of..View full abstract
Awarded by National Institute for Allergy and Infectious Diseases, The National Institute of Health (NIH)
Awarded by National Library of Medicine (NIH)
LC received funding from the National Institute for Allergy and Infectious Diseases, The National Institute of Health (NIH) (U19 AI089672). AB received funding from the National Library of Medicine (NIH) (T32 LM012415). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.