Journal article

Exercise cardiovascular magnetic resonance reveals reduced cardiac reserve in pediatric cancer survivors with impaired cardiopulmonary fitness

Stephen Foulkes, Benedict T Costello, Erin J Howden, Kristel Janssens, Hayley Dillon, Claudia Toro, Piet Claus, Steve F Fraser, Robin M Daly, David A Elliott, Rachel Conyers, Andre La Gerche

Journal of Cardiovascular Magnetic Resonance | BMC | Published : 2020

Abstract

BACKGROUND: Pediatric cancer survivors are at increased risk of cardiac dysfunction and heart failure. Reduced peak oxygen consumption (peak VO2) is associated with impaired cardiac reserve (defined as the increase in cardiac function from rest to peak exercise) and heart failure risk, but it is unclear whether this relationship exists in pediatric cancer survivors. This study sought to investigate the presence of reduced peak VO2 in pediatric cancer survivors with increased risk of heart failure, and to assess its relationship with resting cardiac function and cardiac haemodynamics and systolic function during exercise. METHODS: Twenty pediatric cancer survivors (8-24 years; 10 male) treate..

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Grants

Awarded by A La Gerche's National Heart Foundation Future Leader Fellowship


Awarded by Australian Government Research Training Program Scholarship (RTP)


Funding Acknowledgements

This research was funded, in part, from A La Gerche's National Heart Foundation Future Leader Fellowship (App 102021 "Utility of novel exercise imaging to identify sub-clinical cardiovascular disease"). DAE and RC are supported by the Royal Children's Hospital Foundation, Childrens Cancer Foundation and the Kids Cancer Project. RC is a recipient of an MCRI Clinician-Scientist Fellowship. SF is supported by an Australian Government Research Training Program Scholarship (RTP 4635089552).