Journal article

Determinants of placental leptin receptor gene expression and association with measures at birth

Amanda Vlahos, Toby Mansell, David Burgner, Fiona Collier, Boris Novakovic, Richard Saffery

PLACENTA | W B SAUNDERS CO LTD | Published : 2020


INTRODUCTION: The leptin signalling pathway is important in metabolic health during pregnancy. However, few studies have investigated the determinants and extent of leptin receptor gene (LEPR) expression in the placenta, nor the relationship with infant health in early life. Here, we investigate the genetic and maternal in utero determinants of placental LEPR expression, and whether this expression is linked to anthropometric and inflammatory measures at birth in healthy newborns in the Barwon Infant Study. METHODS: Placental LEPR expression was measured using RT-qPCR (n = 854 placentae). Associations between genetic variation in LEPR, maternal in utero factors, measures at birth and placent..

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Funding Acknowledgements

We thank the Barwon Infant Study participants and their families for taking part in the study, as well as the staff who helped recruit and gather data. We also thank QIMR Berghofer Medical Research Institute and the Erasmus MC University Medical Centre for their role in coordinating and performing the genotyping of BIS samples. The establishment work and infrastructure for the BIS was provided by the Murdoch Children's Research Institute, Deakin University and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund Raising Committee Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited and the Percy Baxter Charitable Trust, Perpetual Trustees. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. B.N. and D. B are supported by an NHMRC Australia CJ Martin Fellowship and Senior Research Fellowship, respectively.