Primary and metastatic breast tumors cross-talk to influence immunotherapy responses
Amanda J Oliver, Simon P Keam, Bianca von Scheidt, Damien J Zanker, Aaron J Harrison, Daniela GM Tantalo, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney
OncoImmunology | TAYLOR & FRANCIS INC | Published : 2020
The presence of a tumor can alter host immunity systematically. The immune-tumor interaction in one site may impact the local immune microenvironment in distal tissues through the circulation, and therefore influence the efficacy of immunotherapies to distant metastases. Improved understanding of the immune-tumor interactions during immunotherapy treatment in a metastatic setting may enhance the efficacy of current immunotherapies. Here we investigate the response to αPD-1/αCTLA4 and trimAb (αDR5, α4-1BB, αCD40) of 67NR murine breast tumors grown simultaneously in the mammary fat pad (MFP) and lung, a common site of breast cancer metastasis, and compared to tumors grown in isolation. Lung tu..View full abstract
Awarded by Cancer Council Victoria
This work was supported by Cancer Australia; the Susan G. Komen Breast Cancer Foundation; the Cancer Council Victoria [Grant-in-aid APP1127757]; NHMRC; NBCF; Australian Postgraduate Award.