Tumour biology characterisation by imaging in clinic

Abstract

There have been advances in multiple imaging modalities in recent decades which allow more sophisticated and non-invasive means of characterising evolving aspects of tumour biology at all stages of their clinical course (i.e. diagnosis, staging, prognostication and therapy response). Particular applications include more accurate staging (e.g. highly sensitive and specific new PET tracers such as Ga-68 DOTATATE and PSMA, diffusion-weighted MRI), assessment of tumour aggressiveness and prognosis (with [18F]FDG PET, CT textural analysis) and tailoring therapy based on either initial assessment (biological dose painting) or interim response assessment ([18F]FDG PET). The field of theranostics ta..