Tyro3 Contributes to Retinal Ganglion Cell Function, Survival and Dendritic Density in the Mouse Retina
Farrah Blades, Vickie HY Wong, Christine TO Nguyen, Bang V Bui, Trevor J Kilpatrick, Michele D Binder
Frontiers in Neuroscience | FRONTIERS MEDIA SA | Published : 2020
Retinal ganglion cells (RGCs) are the only output neurons of the vertebrate retina, integrating signals from other retinal neurons and transmitting information to the visual centers of the brain. The death of RGCs is a common outcome in many optic neuropathies, such as glaucoma, demyelinating optic neuritis and ischemic optic neuropathy, resulting in visual defects and blindness. There are currently no therapies in clinical use which can prevent RGC death in optic neuropathies; therefore, the identification of new targets for supporting RGC survival is crucial in the development of novel treatments for eye diseases. In this study we identify that the receptor tyrosine kinase, Tyro3, is criti..View full abstract
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Awarded by Trish Multiple Sclerosis Research Foundation
Awarded by Australian Research Council Linkage Grant
The authors would like to acknowledge Multiple Sclerosis Research Australia and The Trish Multiple Sclerosis Research Foundation (grant #17-0216) for funding this research project. The Australian Government Research Training Program Scholarship (FB). Australian Research Council Linkage Grant (LP160100126, CTON, BB) and Melbourne Research Fellowships (CTON). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government, particularly, the funding from the Operational Infrastructure Support Grant.