Journal article

Rethinking gastroesophageal reflux disorder.

Samuel P Banting, Henry E Badgery, Matthew Read, Hiroshi Mashimo

Ann N Y Acad Sci | Wiley | Published : 2020

Abstract

Gastroesophageal reflux disease (GERD) is a common clinical condition for which our understanding has evolved over the past decades. It is now considered a cluster of phenotypes with numerous anatomical and physiological abnormalities contributing to its pathophysiology. As such, it is important to first understand the underlying mechanism of the disease process for each patient before embarking on therapeutic interventions. The aim of our paper is to highlight the mechanisms contributing to GERD and review investigations and interpretation of these results. Finally, the paper reviews the available treatment modalities for this condition, ranging from medical intervention, endoscopic options..

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