Journal article

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Brandon J DeKosky

Nature Microbiology | NATURE RESEARCH | Published : 2020

Abstract

Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data from the study of SARS-CoV and other respiratory viruses suggest that anti-SARS-CoV-2 antibodies could exacerbate COVID-19 through antibody-dependent enhancement (ADE). Previous respiratory syncytial virus and dengue virus vaccine studies revealed human clinical safety risks related to ADE, resulting in failed vaccine trials. Here, we describe key ADE mechanisms and discuss mitigation strategies for SARS-CoV-2 vaccines and therapies in development. We also outline recently published data to evaluate the risks and opportu..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC) programme


Awarded by NHMRC


Awarded by United States National Institutes of Health


Funding Acknowledgements

This work was supported by the Victorian government, Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (S.J.K.), an Australian National Health and Medical Research Council (NHMRC) programme grant no. 1149990 (S.J.K.), NHMRC project grant no. 1162760 (A.K.W.), NHMRC fellowships to S.J.K. and A.K.W., the United States National Institutes of Health grant nos. 1DP5OD023118 and R21AI143407 (B.J.D.), the COVID-19 Fast Grants programme (B.J.D.) and the Jack Ma Foundation (B.J.D.).