Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery A Randomized Clinical Trial
Dharshi Karalapillai, Laurence Weinberg, Philip Peyton, Louise Ellard, Raymond Hu, Brett Pearce, Chong O Tan, David Story, Mark O'Donnell, Patrick Hamilton, Chad Oughton, Jonathan Galtieri, Anthony Wilson, Ary Serpa Neto, Glenn Eastwood, Rinaldo Bellomo, Daryl A Jones
JAMA | AMER MEDICAL ASSOC | Published : 2020
Importance: In patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear. Objective: To determine whether low-tidal-volume ventilation compared with conventional ventilation during major surgery decreases postoperative pulmonary complications. Design, Setting, and Participants: Single-center, assessor-blinded, randomized clinical trial of 1236 patients older than 40 years undergoing major noncardiothoracic, nonintracranial surgery under general anesthesia lasting more than 2 hours in a tertiary hospital in Melbourne, Australia, from February 2015 to February 2019. The last date of follow-up was February 17, 2019. Interventions: Patients were randomized to ..View full abstract
Awarded by Australian and New Zealand College of Anaesthetists grant
This study was funded by Australian and New Zealand College of Anaesthetists grant ANZAC16/008.