Journal article

Adrenarcheal hormone-related development of white matter during late childhood

Marjolein EA Barendse, Julian G Simmons, Robert E Smith, Marc L Seal, Sarah Whittle



The aim of the current study was to longitudinally examine how adrenarcheal hormones influence the development of white matter structure from age 8.5 to 10 years. Participants were 120 children (66 female; mean age 8.45 years at Time 1 and 9.97 years at Time 2) who completed two diffusion-weighted imaging scans 1.5 years apart. Morning saliva samples were taken at both assessment time points to measure levels of dehydroepiandrosterone (DHEA), its sulphate (DHEAS), and testosterone. Fixel-based analysis was performed to examine how changes in white matter fibre density (FD) and cross-section (FC) over time were associated with initial levels of hormones, and changes in hormone levels over tim..

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Awarded by Australian Research Council (ARC)

Funding Acknowledgements

The authors declare no competing financial interests. This work was supported by the Australian Research Council (ARC; DP130103551). RS was supported by fellowship funding from the National Imaging Facility (NIF), an Australian Government National Collaborative Research Infrastructure Strategy (NCRIS) capability. This research was conducted at the Children's MRI Centre at the Royal Children's Hospital, Melbourne, Australia. We thank the Royal Children's Hospital Medical Imaging staff for their assistance and expertise in the collection of the MRI data included in this study.