Journal article
Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation
V Grubišić, JL McClain, DE Fried, I Grants, P Rajasekhar, E Csizmadia, OA Ajijola, RE Watson, DP Poole, SC Robson, FL Christofi, BD Gulbransen
Cell Reports | Published : 2020
Open access
Abstract
Grubišić et al. report that enteric glia regulate macrophage activation and visceral sensitivity following intestinal inflammation through mechanisms that require glial connexin-43 (Cx43) and macrophage colony-stimulating factor (M-CSF) production. Proinflammatory signals induce glial Cx43-dependent M-CSF production through protein kinase C (PKC) and tumor necrosis factor (TNF)-alpha converting enzyme (TACE).
Grants
Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by a Crohn's and Colitis Foundation Research Fellowship Award (577598) to V.G., National Institutes of Health (NIH) R01DK103723, R01DK120862, and Crohn's and Colitis Foundation Senior Research Award (327058) to B.D.G., NIH R01DK113943 to F.L.C., a grant from Helmsley Charitable Trust (281574.5069091.0010), and salary support from R01 DK108894 to S.C.R. We acknowledge the University of California Los Angeles Translational Pathology Core laboratory for preparation of paraffin-embedded sections for immunohistochemical studies.