Legionella pneumophilaInfection Rewires theAcanthamoeba castellaniiTranscriptome, Highlighting a Class of Sirtuin Genes
Pengfei Li, Dane Vassiliadis, Sze Ying Ong, Vicki Bennett-Wood, Chihiro Sugimoto, Junya Yamagishi, Elizabeth L Hartland, Shivani Pasricha
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | FRONTIERS MEDIA SA | Published : 2020
Legionella pneumophila is an environmental bacterium that has evolved to survive predation by soil and water amoebae such as Acanthamoeba castellanii, and this has inadvertently led to the ability of L. pneumophila to survive and replicate in human cells. L. pneumophila causes Legionnaire's Disease, with human exposure occurring via the inhalation of water aerosols containing both amoebae and the bacteria. These aerosols originate from aquatic biofilms found in artifical water sources, such as air-conditioning cooling towers and humidifiers. In these man-made environments, A. castellanii supports L. pneumophila intracellular replication, thereby promoting persistence and dissemination of the..View full abstract
Awarded by Australian Research Council (ARC)
This work was supported by an Australian Research Council (ARC) Discovery grant (DP180102725) awarded to EH. PL was supported by a China Scholarship Council-University of Melbourne PhD Scholarship.