Journal article

Emerging connectivity of programmed cell death pathways and its physiological implications

Sammy Bedoui, Marco J Herold, Andreas Strasser



The removal of functionally dispensable, infected or potentially neoplastic cells is driven by programmed cell death (PCD) pathways, highlighting their important roles in homeostasis, host defence against pathogens, cancer and a range of other pathologies. Several types of PCD pathways have been described, including apoptosis, necroptosis and pyroptosis; they employ distinct molecular and cellular processes and differ in their outcomes, such as the capacity to trigger inflammatory responses. Recent genetic and biochemical studies have revealed remarkable flexibility in the use of these PCD pathways and indicate a considerable degree of plasticity in their molecular regulation; for example, d..

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Awarded by Australian National Health and Medical Research Council

Awarded by Leukemia and Lymphoma Society of America

Awarded by Cancer Council of Victoria

Funding Acknowledgements

We are grateful to the present and past members of our laboratories, our collaborators and the mentors that we have had the pleasure of working with. Our work is supported by grants and fellowships from the Australian National Health and Medical Research Council (Project Grants 1186575 and 1145728 to M.J.H., 1143105 to M.J.H. and A.S., 1159658 to M.J.H. and S.B., Program Grant 1016701 to A.S., and Fellowships 1020363, to A.S., and 1156095, to M.J.H.), by the Leukemia and Lymphoma Society of America (grant LLS SCOR 7001-13 to A.S. and M.J.H.), by the Cancer Council of Victoria (project grants 1147328, to M.J.H., and 1052309, to A.S.) and by a Venture Grant to M.J.H. and A.S.