Speech metrics, general disability, brain imaging and quality of life in multiple sclerosis
G Noffs, FMC Boonstra, T Perera, H Butzkueven, SC Kolbe, F Maldonado, LE Cofre Lizama, MP Galea, J Stankovich, A Evans, A van Der Walt, AP Vogel
European Journal of Neurology | WILEY | Published : 2020
BACKGROUND AND PURPOSE: Objective measurement of speech has shown promising results to monitor disease state in multiple sclerosis. In this study, we characterize the relationship between disease severity and speech metrics through perceptual (listener based) and objective acoustic analysis. We further look at deviations of acoustic metrics in people with no perceivable dysarthria. METHODS: Correlations and regression were calculated between speech measurements and disability scores, brain volume, lesion load and quality of life. Speech measurements were further compared between three subgroups of increasing overall neurological disability: mild (as rated by the Expanded Disability Status Sc..View full abstract
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Awarded by National Health and Medical Research Council
This work was supported by the National Health and Medical Research Council (grant numbers 1085461 and 1082910) and by the University of Melbourne (graduate research scholarship).