Journal article

The role of gonadotrophins in gonocyte transformation during minipuberty

Emily Burton, Sanduni Amaya Abeydeera, Gulcan Sarila, Hyun-Jung Cho, Shengde Wu, Melissa Yixin Tien, John Hutson, Ruili Li

Pediatric Surgery International | SPRINGER | Published : 2020

Abstract

PURPOSE: Postnatal surge of gonadotrophins, Luteinizing hormone (LH) and Follicle-Stimulating hormone (FSH) known as minipuberty, is critical for gonocyte maturation into spermatogonial stem cells (SSC) in the testis. Gonadotrophins are essential for optimum fertility in men, but very little is known how they regulate germ cells during minipuberty. This study examined whether gonadotrophins play a role on gonocyte transformation in vivo. METHODS: Testes from hypogonadal (hpg) mice and their wild type (WT) littermates (n = 6/group) were weighed, and processed in paraffin at postnatal days (D) 0, 3, 6 and 9. Mouse VASA homologue (germ cell marker), anti-Müllerian hormone (Sertoli cell marker) ..

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Grants

Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

This study was funded by the Australian National Health and Medical Research Council (Grant no. APP1127109) and the Victorian Government's Operational Infrastructure Support Program.