Journal article

Whole blood flow cytometry protocol for the assessment of platelet phenotype, function, and cellular interactions

Hui Ping Yaw, Suelyn van den Helm, Matthew Linden, Paul Monagle, Vera Ignjatovic

Platelets | TAYLOR & FRANCIS INC | Published : 2020

Abstract

Platelets are a key component of the hemostatic system and their roles in inflammation via interactions with leukocytes have also gained attention in recent years. Changes in platelet phenotype and function can cause bleeding and/or thrombosis and, as such, monitoring platelet-specific changes is crucial to assessing hemostasis in the clinical setting. Currently, available platelet function tests such as platelet aggregometry and thromboelastography require a large volume of blood, which is a major limitation for the pediatric population. Whole blood flow cytometric analysis of platelets is increasingly utilized in recent years, primarily due to the sensitivity of this method, but also becau..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

This study was funded by National Health and Medical Research Council (NHMRC), [Grant Number 1129317].