An altered glial phenotype in the NL3(R451C) mouse model of autism
Samantha M Matta, Zachery Moore, Frederick Rohan Walker, Elisa L Hill-Yardin, Peter J Crack
Scientific Reports | NATURE RESEARCH | Published : 2020
Autism Spectrum Disorder (ASD; autism) is a neurodevelopmental disorder characterised by deficits in social communication, and restricted and/or repetitive behaviours. While the precise pathophysiologies are unclear, increasing evidence supports a role for dysregulated neuroinflammation in the brain with potential effects on synapse function. Here, we studied characteristics of microglia and astrocytes in the Neuroligin-3 (NL3R451C) mouse model of autism since these cell types are involved in regulating both immune and synapse function. We observed increased microglial density in the dentate gyrus (DG) of NL3R451C mice without morphological differences. In contrast, WT and NL3R451C mice had ..View full abstract
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Awarded by Australian Research Council Future Fellowship
This study was supported by the following funding sources: National Health and Medical Research Council project grant to P.J.C, Australian Research Council Future Fellowship (FT160100126) and RMIT Vice-Chancellor's Senior Research Fellowship to E.L.H-Y.