Gene expression in bovine endometrial cells and blood-derived neutrophils stimulated by uterine secretions
Maren Hillmer, Christina Deborah Marth, Marie Margarete Meyerholz, Daniela Klaus-Halla, Heinz-Adolf Schoon, Frank Weber, Hans-Joachim Schuberth, Holm Zerbe
Theriogenology | ELSEVIER SCIENCE INC | Published : 2020
Uterine epithelial cells (UEC) and migrated polymorphonuclear cells (PMN) play important roles in the uterine defence against microbial infection. The aims of the present study were to investigate i) whether undiluted uterine secretions modulate the expression of genes associated with the innate immune response in UEC and PMN in vitro, ii) whether these changes differ between the two cell populations and iii) whether uterine secretions from cows with subclinical endometritis produce a different response to those from unaffected cows. Therefore, undiluted uterine secretions, cytobrush and biopsy samples were collected from bovine uteri at a local abattoir. All cows had calved at least 3 month..View full abstract
This study was supported by the J&G Bruns Stiftung for innovate veterinary medicine.