Emerging Technologies to Solve the Key Issues in Endothelial Keratoplasty

Abstract

Purpose of Review: Endothelial keratoplasty (EK) is increasingly used to treat corneal endothelial disease. However, issues remain with EK including a non-zero rejection rate, shortage of donor tissue, and technical challenges for Descemet’s membrane endothelial keratoplasty. Technologies that might solve these issues include small-molecule drugs, surgical innovations, cell therapy, tissue engineering, and gene therapy. Our purpose is to inform ophthalmologists, eye bankers, and eye health professionals of technologies that could impact practice in the near future. Recent Findings: Recent advances are targeted at solving known issues with EK. Although none is yet routine, some are in clinica..