Journal article

Human gamma delta T cells recognize CD1b by two distinct mechanisms

Josephine F Reijneveld, Tonatiuh A Ocampo, Adam Shahine, Benjamin S Gully, Pierre Vantourout, Adrian C Hayday, Jamie Rossjohn, D Branch Moody, Ildiko Van Rhijn

Proceedings of the National Academy of Sciences of USA | NATL ACAD SCIENCES | Published : 2020

Abstract

γδ T cells form an abundant part of the human cellular immune system, where they respond to tissue damage, infection, and cancer. The spectrum of known molecular targets recognized by Vδ1-expressing γδ T cells is becoming increasingly diverse. Here we describe human γδ T cells that recognize CD1b, a lipid antigen-presenting molecule, which is inducibly expressed on monocytes and dendritic cells. Using CD1b tetramers to study multiple donors, we found that many CD1b-specific γδ T cells use Vδ1. Despite their common use of Vδ1, three CD1b-specific γδ T cell receptors (TCRs) showed clear differences in the surface of CD1b recognized, the requirement for lipid antigens, and corecognition of butr..

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University of Melbourne Researchers

Grants

Awarded by NIH


Awarded by Australian Research Council


Awarded by Wellcome Trust Investigator Award


Funding Acknowledgements

This work is supported by the NIH (Grants AI049313, AR048632) and the Australian Research Council (Grant CE140100011). A.C.H. and P.V. were supported by Wellcome Trust Investigator Award 106292/Z/14/Z. J.R. is supported by an Australian Research Council Laureate fellowship. The CD1a and CD1b monomers were made available by the NIH Tetramer Core Facility.