Occupational silica exposure in an Australian systemic sclerosis cohort
Shreeya Patel, Kathleen Morrisroe, Susanna Proudman, Dylan Hansen, Joanne Sahhar, Malcolm R Sim, Gene-Siew Ngian, Jenny Walker, Gemma Strickland, Michelle Wilson, Nava Ferdowsi, Gabor Major, Janet Roddy, Wendy Stevens, Mandana Nikpour
RHEUMATOLOGY | OXFORD UNIV PRESS | Published : 2020
Objective To determine the frequency of self-reported occupational exposure to silica in SSc patients enrolled in the Australian Scleroderma Cohort Study, and to compare the disease characteristics of the silica-exposed patients with those of the non-exposed patients. Method Data collected over a 12-year period from 1670 SSc patients were analysed. We compared the demographic and clinical characteristics of those who reported occupational silica exposure with those who did not. A subgroup analysis of male patients was performed, as well as a multivariable analysis of correlates of silica exposure. Results Overall, 126 (7.5%) of the cohort reported occupational silica exposure. These indivi..View full abstract
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Awarded by National Health and Medical Research Council of Australia Career Development Fellowship
The Australian Scleroderma Cohort Study (ASCS) is supported by Actelion Australia, Scleroderma Australia, Scleroderma Victoria, Arthritis Australia, Musculoskeletal Australia, The Scleroderma Clinical Trials Consortium (SCTC), St Vincent's Hospital Research Endowment Fund, The Australian Rheumatology Association, philanthropic donations, GlaxoSmithKline, Roche, Pfizer, Bayer, CSL Biotherapies and Bristol-Myers Squibb. M.N. holds a National Health and Medical Research Council of Australia Career Development Fellowship (APP 1126370).