Journal article
Osteoporosis in Parkinson's Disease: Relevance of Distal Radius Dual-Energy X-Ray Absorptiometry (DXA) and Sarcopenia
YJ Tan, SY Lim, VW Yong, XY Choo, YD Ng, K Sugumaran, MN Md Shah, RRA Raja Aman, SS Paramasivam, N Mohd Ramli, M Grossmann, AH Tan
Journal of Clinical Densitometry | ELSEVIER SCIENCE INC | Published : 2021
Abstract
Osteoporotic fractures are common in Parkinson's disease (PD). Standard dual-energy X-ray absorptiometry (DXA) measuring bone mineral density (BMD) at the femoral neck and lumbar spine (central sites) has suboptimal sensitivity in predicting fracture risk in the general population. An association between sarcopenia and osteoporosis in PD has not been studied. We compared BMD and osteoporosis prevalence in PD patients vs controls; determined the osteoporosis detection rates using central alone vs central plus distal radius DXA; and analyzed factors (in particular, sarcopenia) associated with osteoporosis. One hundred and fifty-six subjects (102 patients with PD, 54 spousal/sibling controls) u..
View full abstractGrants
Awarded by Ministry of Higher Education, Malaysia
Funding Acknowledgements
This work was supported by the University of Malaya Faculty Research Grant (GPF018C-2018), the Ministry of Higher Education Malaysia Fundamental Research Grant (FRGS; FP018-2019A), and a donation from the family of the late Mr. Chua Kian Lee. These funding sources had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.