Osteoporosis in Parkinson's Disease: Relevance of Distal Radius Dual-Energy X-Ray Absorptiometry (DXA) and Sarcopenia.
Yan Jing Tan, Shen-Yang Lim, Voon Wei Yong, Xing Yan Choo, Yi-De Ng, Kavita Sugumaran, Mohammad Nazri Md Shah, Raja Rizal Azman Raja Aman, Sharmila Sunita Paramasivam, Norlisah Mohd Ramli, Mathis Grossmann, Ai Huey Tan
Journal of Clinical Densitometry | Published : 2020
Osteoporotic fractures are common in Parkinson's disease (PD). Standard dual-energy X-ray absorptiometry (DXA) measuring bone mineral density (BMD) at the femoral neck and lumbar spine (central sites) has suboptimal sensitivity in predicting fracture risk in the general population. An association between sarcopenia and osteoporosis in PD has not been studied. We compared BMD and osteoporosis prevalence in PD patients vs controls; determined the osteoporosis detection rates using central alone vs central plus distal radius DXA; and analyzed factors (in particular, sarcopenia) associated with osteoporosis. One hundred and fifty-six subjects (102 patients with PD, 54 spousal/sibling controls) u..View full abstract