Journal article

Risk of Dementia in Posttraumatic Stress Disorder

Alby Elias, Christopher Rowe, Malcolm Hopwood

Journal of Geriatric Psychiatry and Neurology | SAGE PUBLICATIONS INC | Published : 2020


Several studies have investigated the risk of dementia in posttraumatic stress disorder (PTSD) using a varying methodology. Epidemiological studies have found an increased risk of dementia with PTSD in Vietnam veterans as well as the general population. Laboratory studies reported the accelerated formation of β-amyloid and tau, which represent the primary pathology of Alzheimer's dementia in animal models of PTSD. These investigations were conducted against a background of cognitive impairment and atrophy of the hippocampus and certain cortical areas in patients with PTSD. Very few studies have investigated the pathological basis in humans for the reported association of PTSD with dementia. ..

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