Journal article

Role of levosimendan in weaning children requiring veno-arterial extracorporeal membrane oxygenation after cardiac surgery

Kevin C Pan, Sai Shankar, Johnny Millar, Roberto Chiletti, Warwick Butt, Yves d'Udekem, Siva P Namachivayam

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | OXFORD UNIV PRESS INC | Published : 2021

Abstract

OBJECTIVES: Levosimendan use is associated with more successful decannulation from veno-arterial extracorporeal membrane oxygenation (VA ECMO) in adults. We sought to determine the role of levosimendan in children who required VA ECMO after cardiac surgery. METHODS: This observational study compares the outcomes of children who required VA ECMO after cardiac surgery and received levosimendan for weaning with those who did not receive the drug. A doubly robust estimation methodology (inverse probability of treatment weighting with regression adjustment) was used to balance study covariates (age, weight, sex, lactate pre-ECMO, vasoactive-inotropic score pre-ECMO, ECMO indication, ECMO modality..

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Grants

Awarded by National Heart Foundation of Australia


Funding Acknowledgements

The authors thank Jennifer Lewis, B.Pharm (Hons), Clinical Pharmacist, Royal Children's Hospital for providing us with a list of patients who received levosimendan. The authors also thank Derek Best, B.N, for providing us with study information from the departmental ECLS database. Dr Namachivayam is supported by a health professional research scholarship (award no: 101003) from the National Heart Foundation of Australia.