Journal article

Early life interaction between the microbiota and the enteric nervous system

Jaime PP Foong, Lin Y Hung, Sabrina Poon, Tor C Savidge, Joel C Bornstein

AJP Gastrointestinal and Liver Physiology | AMER PHYSIOLOGICAL SOC | Published : 2020


Recent studies on humans and their key experimental model, the mouse, have begun to uncover the importance of gastrointestinal (GI) microbiota and enteric nervous system (ENS) interactions during developmental windows spanning from conception to adolescence. Disruptions in GI microbiota and ENS during these windows by environmental factors, particularly antibiotic exposure, have been linked to increased susceptibility of the host to several diseases. Mouse models have provided new insights to potential signaling factors between the microbiota and ENS. We review very recent work on maturation of GI microbiota and ENS during three key developmental windows: embryogenesis, early postnatal, and ..

View full abstract


Awarded by National Health and Medical Research Council of Australia Project

Funding Acknowledgements

This research was supported by National Health and Medical Research Council of Australia Project Grants APP1099016 to J. P. P. Foong, J. C. Bornstein, and T. C. Savidge and P30-DK56338, PO1-AI152999, U01-AI24290, and R01-AI10091401 to T. C Savidge, as well as the University of Melbourne International Research and Fee Remission Scholarship to L. Y. Hung.