Journal article
A novel way to quantify schizophrenia symptoms in clinical trials
ON Medvedev, M Berk, OM Dean, E Brown, MH Sandham, JF Dipnall, RK McNamara, A Sumich, CU Krägeloh, A Narayanan, RJ Siegert
European Journal of Clinical Investigation | WILEY | Published : 2021
DOI: 10.1111/eci.13398
Open access
Abstract
Background: A major problem in quantifying symptoms of schizophrenia is establishing a reliable distinction between enduring and dynamic aspects of psychopathology. This is critical for accurate diagnosis, monitoring and evaluating treatment effects in both clinical practice and trials. Materials and methods: We applied Generalizability Theory, a robust novel method to distinguish between dynamic and stable aspects of schizophrenia symptoms in the widely used Positive and Negative Symptom Scale (PANSS) using a longitudinal measurement design. The sample included 107 patients with chronic schizophrenia assessed using the PANSS at five time points over a 24-week period during a multi-site clin..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors declare no conflicts of interest in regards of this paper. MB is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1059660 and 1156072). This article resulted from a meeting of the authors in April 2017 funded by a Royal Society of New Zealand Catalyst (Seeding General) Grant awarded to RS in 2016 16-AUT-024-CSG.