Journal article

A novel way to quantify schizophrenia symptoms in clinical trials

Oleg N Medvedev, Michael Berk, Olivia M Dean, Ellie Brown, Margaret H Sandham, Joanna F Dipnall, Robert K McNamara, Alexander Sumich, Christian U Krageloh, Ajit Narayanan, Richard J Siegert

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | WILEY | Published : 2020

Abstract

BACKGROUND: A major problem in quantifying symptoms of schizophrenia is establishing a reliable distinction between enduring and dynamic aspects of psychopathology. This is critical for accurate diagnosis, monitoring and evaluating treatment effects in both clinical practice and trials. MATERIALS AND METHODS: We applied Generalizability Theory, a robust novel method to distinguish between dynamic and stable aspects of schizophrenia symptoms in the widely used Positive and Negative Symptom Scale (PANSS) using a longitudinal measurement design. The sample included 107 patients with chronic schizophrenia assessed using the PANSS at five time points over a 24-week period during a multi-site clin..

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