Journal article

Biased MAIT TCR Usage Poised for Limited Antigen Diversity?

Michael NT Souter, Sidonia BG Eckle

FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2020

Abstract

Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize the evolutionarily conserved major histocompatibility complex (MHC) class I-like antigen-presenting molecule known as MHC class I related protein 1 (MR1). Since their rise from obscurity in the early 1990s, the study of MAIT cells has grown substantially, accelerating our fundamental understanding of these cells and their possible roles in immunity. In the context of recent advances, we review here the relationship between MR1, antigen, and TCR usage among MAIT and other MR1-reactive T cells and provide a speculative discussion.

Grants

Awarded by Australian Research Council (ARC)


Awarded by Australian National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

SE was supported by a fellowship from the Australian Research Council (ARC), (ARC DECRA DE170100407) and a project grant from the Australian National Health and Medical Research Council (NHMRC project Grant No. GNT1157388).