Journal article

Bronchial Rheoplasty for Treatment of Chronic Bronchitis Twelve-Month Results from a Multicenter Clinical Trial

Arschang Valipour, Sebastian Fernandez-Bussy, Alvin J Ing, Daniel P Steinfort, Gregory Snell, Jonathan P Williamson, Tajalli Saghaie, Louis B Irving, Eli J Dabscheck, William S Krimsky, Jonathan Waldstreicher

American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2020


Rationale: Chronic bronchitis (CB) is characterized by productive cough with excessive mucus production, resulting in quality-of-life impairment and increased exacerbation risk. Bronchial rheoplasty uses an endobronchial catheter to apply nonthermal pulsed electrical fields to the airways. Preclinical studies have demonstrated epithelial ablation followed by regeneration of normalized epithelium.Objectives: To evaluate the feasibility, safety, and initial outcomes of bronchial rheoplasty in patients with CB.Methods: Pooled analysis of two separate studies enrolling 30 patients undergoing bilateral bronchial rheoplasty was conducted. Follow-up through 6 months (primary outcome) and 12 months ..

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