Journal article

Evolution of immunity to SARS-CoV-2

Adam Wheatley, Jennifer Juno, Jing Wang, Kevin Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen Wragg, Hannah Kelly, Robyn Esterbauer, Samantha Davis, Helen Kent, Francesca Mordant, Timothy Schlub, David Gordon, David Khoury, Kanta Subbarao, Deborah Cromer, Tom Gordon, Amy Chung Show all

Cold Spring Harbor Laboratory | Published : 2020


The durability of infection-induced SARS-CoV-2 immunity has major implications for public health mitigation and vaccine development. Animal studies 1,2 and the scarcity of confirmed re-infection 3 suggests immune protection is likely, although the durability of this protection is debated. Lasting immunity following acute viral infection requires maintenance of both serum antibody and antigen-specific memory B and T lymphocytes and is notoriously pathogen specific, ranging from life-long for smallpox or measles 4 , to highly transient for common cold coronaviruses (CCC) 5 . Neutralising antibody responses are a likely correlate of protective immunity and exclusively recognise the viral spike ..

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