Journal article

Biliverdin and bilirubin sulfonate inhibit monosodium urate induced sterile inflammation in the rat

Ryan G Shiels, Wenu Hewage, Evan N Pennell, Josif Vidimce, Gary Grant, Andrew G Pearson, Karl-Heinz Wagner, Michael Morgan, Andrew C Bulmer

European Journal of Pharmaceutical Sciences | ELSEVIER | Published : 2020

Abstract

BACKGROUND: Biliverdin, a by-product of haem catabolism, possesses potent endogenous antioxidant and anti-inflammatory properties. Bilirubin-C10-sulfonate (BRS), an active metabolite formed after enteral administration of BV in the rat, also possess antioxidant properties. Therefore, we investigated the anti-inflammatory and antioxidant activity of BV and BRS in an in vivo model of monosodium urate induced sterile inflammation. METHODS: Subcutaneous air pouches were created on the dorsal flanks of Wistar rats (10-12 weeks of age). Prior to stimulation of the 6-day old pouch with monosodium urate (25 mg), groups were pre-treated with intraperitoneal BRS (27 mg/kg) and BV (27 mg/kg). Total and..

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University of Melbourne Researchers

Grants

Funding Acknowledgements

The authors acknowledge the support received through an Australian Government Research Training Program Scholarship as well as the generosity of Patricia Barlow in providing a Research Higher Degree scholarship. The research was supported by the Griffith Enterprise Innovation Fund, which utilised funding provided by Griffith University and the Queensland Government.