Biliverdin and bilirubin sulfonate inhibit monosodium urate induced sterile inflammation in the rat
Ryan G Shiels, Wenu Hewage, Evan N Pennell, Josif Vidimce, Gary Grant, Andrew G Pearson, Karl-Heinz Wagner, Michael Morgan, Andrew C Bulmer
European Journal of Pharmaceutical Sciences | ELSEVIER | Published : 2020
BACKGROUND: Biliverdin, a by-product of haem catabolism, possesses potent endogenous antioxidant and anti-inflammatory properties. Bilirubin-C10-sulfonate (BRS), an active metabolite formed after enteral administration of BV in the rat, also possess antioxidant properties. Therefore, we investigated the anti-inflammatory and antioxidant activity of BV and BRS in an in vivo model of monosodium urate induced sterile inflammation. METHODS: Subcutaneous air pouches were created on the dorsal flanks of Wistar rats (10-12 weeks of age). Prior to stimulation of the 6-day old pouch with monosodium urate (25 mg), groups were pre-treated with intraperitoneal BRS (27 mg/kg) and BV (27 mg/kg). Total and..View full abstract
The authors acknowledge the support received through an Australian Government Research Training Program Scholarship as well as the generosity of Patricia Barlow in providing a Research Higher Degree scholarship. The research was supported by the Griffith Enterprise Innovation Fund, which utilised funding provided by Griffith University and the Queensland Government.