Journal article

Feelings of depression, pain and walking difficulties have the largest impact on the quality of life of people with multiple sclerosis, irrespective of clinical phenotype

Yan Zhang, Bruce Taylor, Steve Simpson, Leigh Blizzard, Julie A Campbell, Andrew J Palmer, Ingrid van der Mei

Multiple Sclerosis Journal | SAGE PUBLICATIONS LTD | Published : 2020


BACKGROUND: The symptoms that have the largest impact on health-related quality of life (HRQoL) in people with multiple sclerosis (MS) may vary by MS phenotype (relapsing-remitting MS (RRMS), secondary progressive MS (SPMS) and primary progressive MS (PPMS)). Knowing these symptoms assists in symptom management. OBJECTIVE: To examine the associations between 13 common MS symptoms and HRQoL in the total sample and stratified by MS phenotype. METHOD: The study included 1985 participants. HRQoL was measured with two multi-attribute utility instruments: assessment of quality of life with eight dimensions (AQoL-8D) and European quality of life with five dimensions and five levels for each dimensi..

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Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by MS Research Australia. We sincerely thank all participants of the Australian MS Longitudinal Study for their support and willingness to complete surveys.