Journal article

Genetic Susceptibility to Atrial Fibrillation Is Associated With Atrial Electrical Remodeling and Adverse Post-Ablation Outcome

Geoffrey R Wong, Chrishan J Nalliah, Geoffrey Lee, Aleksandr Voskoboinik, Sandeep Prabhu, Ramanathan Parameswaran, Hariharan Sugumar, Robert D Anderson, Liang-Han Ling, Alex McLellan, Renee Johnson, Prashanthan Sanders, Peter M Kistler, Diane Fatkin, Jonathan M Kalman

JACC Clinical Electrophysiology | ELSEVIER | Published : 2020


Objectives This study sought to assess the atrial electrophysiological properties and post-ablation outcomes in patients with atrial fibrillation (AF) with and without the rs2200733 single nucleotide variant. Background The phenotype associated with chromosome 4q25 of the AF-susceptibility locus remains unknown. Methods In this study, 102 consecutive patients (ages 61 ± 9 years, 64% male) with paroxysmal or persistent AF were prospectively recruited prior to ablation. Patients were genotyped for rs2200733 and high-density left atrial (LA) electroanatomic maps were created using a multipolar catheter during distal coronary sinus (CS) pacing at 600 ms. Voltage, conduction velocity (CV), CV h..

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