Journal article

Sympathetic nerves control bacterial clearance

Yugeesh R Lankadeva, Clive N May, Michael J McKinley, Melanie R Neeland, Shuai Ma, Dianna M Hocking, Roy Robins-Browne, Sammy Bedoui, David GS Farmer, Simon R Bailey, Davide Martelli, Robin M McAllen

SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2020

Abstract

A neural reflex mediated by the splanchnic sympathetic nerves regulates systemic inflammation in negative feedback fashion, but its consequences for host responses to live infection are unknown. To test this, conscious instrumented sheep were infected intravenously with live E. coli bacteria and followed for 48 h. A month previously, animals had undergone either bilateral splanchnic nerve section or a sham operation. As established for rodents, sheep with cut splanchnic nerves mounted a stronger systemic inflammatory response: higher blood levels of tumor necrosis factor alpha and interleukin-6 but lower levels of the anti-inflammatory cytokine interleukin-10, compared with sham-operated ani..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Future Leader Fellowship by the National Heart Foundation of Australia (NHF)


Funding Acknowledgements

This study was supported by a grant from the National Health and Medical Research Council of Australia (NHMRC, APP1186382). YRL was supported by a Future Leader Fellowship by the National Heart Foundation of Australia (NHF; 101853).