Journal article

Association of Pregnancy With the Onset of Clinically Isolated Syndrome

Ai-Lan Nguyen, Karolina Vodehnalova, Tomas Kalincik, Alessio Signori, Eva Kubala Havrdova, Jeannette Lechner-Scott, Olga G Skibina, Alana Eastaugh, Lisa Taylor, Josephine Baker, Nicola McGuinn, Louise Rath, Vicki Maltby, Maria Pia Sormani, Helmut Butzkueven, Anneke van der Walt, Dana Horakova, Vilija G Jokubaitis



Importance Multiple sclerosis (MS) is usually diagnosed in women during their childbearing years. Currently, no consensus exists on whether pregnancy can delay the first episode of demyelination or clinically isolated syndrome (CIS). Objective To investigate the association of pregnancy with time to CIS onset. Design, Setting, and Participants This multicenter cohort study collected reproductive history (duration of each pregnancy, date of delivery, length of breastfeeding) on all participants between September 1, 2016, and June 25, 2019. Adult women being treated at the MS outpatient clinics of 4 tertiary hospitals in 2 countries (Charles University and General University Hospital in P..

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Awarded by NHMRC

Funding Acknowledgements

This study was supported by a Postgraduate Scholarship and Ian Ballard Travel Award from MS Research Australia (Dr Nguyen), by an Australian Government Research Training Program Scholarship (Dr Nguyen), and by grant 1156519 from NHMRC (Dr Jokubaitis). The MSBase Foundation, which administers the MSBase Registry used in this study, is a not-for-profit organization that receives support from Roche, Merck, Biogen, Novartis, Bayer Schering, Sanofi Genzyme, and Teva.