Journal article

Total Antioxidant Capacity and Frailty in Older Men

Monica C Tembo, Kara L Holloway-Kew, Chiara C Bortolasci, Sophia X Sui, Sharon L Brennan-Olsen, Lana J Williams, Mark A Kotowicz, Julie A Pasco



Frailty, a clinical syndrome characterized by multisystem dysregulation, has been associated with high levels of oxidative stress. We investigated the association between serum total antioxidant capacity (TAC) and frailty in older men. This cross-sectional study included 581 men (age 60-90 years) enrolled in the Geelong Osteoporosis Study. Frailty comprised at least three of unintentional weight loss, exhaustion, low physical activity, slowness, and weakness. Serum TAC was measured by quantitative colorimetric determination and expressed as uric acid equivalents (mM). Relationships between TAC (in SD units) and frailty were explored using multivariable logistic regression models. Sociodemogr..

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Awarded by National Health and Medical Research Council (NHMRC) Australia

Awarded by NHMRC Career Development Fellowships

Awarded by NHMRC Career Development Fellowship

Awarded by NHMRC Investigator grant

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Health and Medical Research Council (NHMRC) Australia (projects 299831, 628582). The funding organization played no role in the design or conduct of the study, in the collection, management, analysis, and interpretation of the data, nor in the preparation, review, and approval of the manuscript. MCT and SXS were supported by Deakin Postgraduate Scholarships, KLH-K and CCB were supported by Alfred Deakin Postdoctoral Research Fellowship; SLB-O was supported by NHMRC Career Development Fellowships (1107510) and LJW is supported by an NHMRC Career Development Fellowship (1064272) and a NHMRC Investigator grant (1174060).