Journal article

Undercarboxylated osteocalcin has no adverse effect on endothelial function in rabbit aorta or human vascular cells

Alexander Tacey, Sophie Millar, Tawar Qaradakhi, Cassandra Smith, Alan Hayes, Susan Anderson, Anthony Zulli, Saoirse O'Sullivan, Itamar Levinger

Journal of Cellular Physiology | WILEY | Published : 2020

Abstract

Undercarboxylated osteocalcin (ucOC) improves glucose metabolism; however, its effects on endothelial cell function are unclear. We examined the biological effect of ucOC on endothelial function in animal models ex vivo and human cells in vitro. Isometric tension and immunohistochemistry techniques were used on the aorta of male New Zealand white rabbits and cell culture techniques were used on human aortic endothelial cells (HAECs) to assess the effect of ucOC in normal and high-glucose environments. Overall, ucOC, both 10 and 30 ng/ml, did not significantly alter acetylcholine-induced blood vessel relaxation in rabbits (p > .05). UcOC treatment did not cause any significant changes in the ..

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University of Melbourne Researchers