Journal article

Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease

Christine L West, Yu-Kang Mao, Thilini Delungahawatta, Jessica Y Amin, Sohana Farhin, Rachel M McQuade, Shanti Diwakarla, Ruslan Pustovit, Andrew M Stanisz, John Bienenstock, Denise Barbut, Michael Zasloff, John B Furness, Wolfgang A Kunze

Journal of Parkinson's Disease | IOS PRESS | Published : 2020

Abstract

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder thought to be caused by accumulation of α-synuclein (α-syn) within the brain, autonomic nerves, and the enteric nervous system (ENS). Involvement of the ENS in PD often precedes the onset of the classic motor signs of PD by many years at a time when severe constipation represents a major morbidity. Studies conducted in vitro and in vivo, have shown that squalamine, a zwitterionic amphipathic aminosterol, originally isolated from the liver of the dogfish shark, effectively displaces membrane-bound α-syn. Objective: Here we explore the electrophysiological effect of squalamine on the gastrointestinal (GI) tract o..

View full abstract

Grants

Awarded by Natural Sciences and Engineering Research Council of Canada


Funding Acknowledgements

This study was supported by grants from Enterin Inc. and the Natural Sciences and Engineering Research Council of Canada Discovery Grant (2014-05517) awarded to W.A.K. Takeda Pharmaceuticals, Inc. provided support to the experiments conducted in the Florey Institute.